When i was hot rodding my #1, I was shooting a 350gr hornady at a touch over 1800fps, i think I used 60gr of h335. That was a beast off the bench. I did load up some 450gr cast bullets and that I didn't finish the box of. I let a guy shoot it, and his words were "that is violence personified" . 

I guess a good question is what are you loading for? One of the guys I shot with did an African hunt every year (rich farmer) and said the 350gr load was more than enough to go through an elephant skull

I'm always happy to help a guy out with recoil. I started to tear my shoulder tenons with my 45/70 back in the '90's and had rotor cuff surgery in about 2007.

Lyman #46 list a 405 gr, Win SP jacketed at 2157 fps, with 60 gr RX7at only 37,500 CUP, 2.735 OAL.
Speer 405 gr FN J, 2113 fps with 57.0 gr RX7 at 37k CUP, 2.64 OAL.
500 gr Hornaday, J at 1879 fps, with 57.0 gr H4895 and 39k CUP, 2.930 OAL.

If you want serious Griz protection, and enough recoil that you can barely hang on to the rifle, you need a 8 bore double, with a 1080 gr bullet.

I like the 8 bore hole but such rifles are not in my budget range .
Biggest medicine I can afford is a 12 bore H&R handy rifle. With about an 800 grain 73 caliber full bore slug it brings misery  into sharp focus.

With 45-70 rifles ranging  from an 1885 HW Winchester, through a 1914 Model 1886 original half magazine,  1878 Sharps Borchardt, an earlier no-extra safety 1895 Marlin, to an earlier Shiloh Sharps ...agree that there many pressure levels to the 45-70 GOVT cartridge. My pressures and velocities with 405 gr cast bullets are generally at the mid to  lower end.

For more required performance  levels as in  serious Alaskan use, I prefer the early 1886 nickle steel or the Model 71 Winchester in the 450 Alaskan or 450 Fuller wildcats on the 348 WCF case.
With homestead land in the Interior, bears can be a real issue.
Reliability and accurate  controlled repeat shots are the necessary requisites, not high velocity or higher pressure handloads. Velocities for a 400 gr jacketed bonded-core bullet are in the 45-90 WCF range and function well.
They actually seem to be more accurate than similar results from a .50 Alaskan with 450 gr bullets in a similar Model 71.