The centerfire rifle barrels will not interchange between  models.

In my experience, yess and no. There were two variations and parts are not interchangeable. Barrels may interchange on the same variation but not necessarily.

The 219 & 220 used the same receivers and barrels if they are the same version & vintage, barrels should interchange with some minor fitting possibly needed for the latch engagement.  The parts catalogs have both together and as mentioned above Savage marketed a number of rifle shotgun combination sets. I don't have any rifle barrels but have swapped shotgun barrels on the 220 & 220A's without a problem, they even fit on a Stevens 94 shotgun in .410. There was some variation in how much the latches engaged but all closed. I know of some collectors who have tried to acquire every caliber & gauge barrel to use on one receiver. 

There is a good writeup here - (You need to Login or Register to view media files and links)