Ball powders are a "piece of cake" with most measures. As has been said, many times, it's your consistency that matters.
4227, is not very hard to throw. It was the first powder I used and because no one had anything else in stock, I had to buy a RCBS, Little Dandy, with a rotor that threw 13.+ gr. I had a hard time getting the scale to very with it. In part because that little rotor thimble, didn't let you very your technique to much
I have collected powder measures, ever since and I try each one out by setting them to about 15.0 gr and throw a few individual charges and then throwing multiple 10's and weighing them, to average how well it throws.
In all my years, I haven't found one that throws better than my Redding, with the pistol insert (5/16 dia insert) and my double baffle (powder above the baffle), for charges up to 20 gr.
The micrometer adjustment, always repeats itself, too! I have a book with at least 20 powders and mic settings for above and below the range I use for them. I also made two rotors .500 for +/- 30 gr (CBA matches) and one that is only .200, for 1.0 - 5 gr, for BSing my 22rf.
Now, I must say, that I have never bought or used a Harrels, mainly because I consider them over priced for the needed use (I truly don't think my measure can be improved upon) BUT, if they would measure 4759 better than a B&M, they might have value. Has anyone test them in that application?? But, then it wouldn't really matter, would it
Pictured are about 2/3 of my measures (all that would fit my stand).