Marlin Guy's offered some good words of advice.
I suppose if you stay within known publisher load data guidelines your safe. Maybe...
Reduced powder charges can be problematic from what I read for a number of reasons.
S.E.E. or Secondary Explosion Effect, from what I have read, is responsible for a number of destroyed guns.
Search 'Ringed Chambers' as well.
In addition to what Marlin guy said,
Age of the gun.. Steel, action strength, primers, cast vs. jacketed, crimp vs. no crimp, seating depth, etc.
I am a novice shooter but I've being reading published information on the subject (internal ballistics) for 50 years.
A good read would be Franklin W. Mann's,
THE BULLETS FLIGHT,
THE BALLISTICS OF SMALL ARMS
Jeff_Schultz wrote on Sep 16
th, 2022 at 8:43pm:
Nothing to worry about.