How does unique powder work in a forty five colt  with a 250 gn bullet in a single shot rifle with all modern parts ( Ruger #1)? Thanks for your answer, Hank45 

I've burned up a LOT of Unique in several different big bore pistol loads. It was my go-to powder since I started shooting them nearly 50 years ago.   I've used up a lot of my 44m Unique-charged ammo in my little Ruger lever-action carbine-----I need to sit down and do a marathon 44m reloading session later this winter. 
  I think a restocked #3 in 44M (or one of the .45 LC and its larger variations) would make a perfect little woods rifle---an American "stalking rifle" for game up and including midwest whitetail.

Thats about all I used it for though.  After reading about those gun-blow-ups I probably became over-conscious of small volume charges of "faster" powders in large volume cases.
   When I started my single shot journey with an early version Miroku-wall in 45-70 I saw some Unique loads listed,  but thinking of it as a "pistol powder" I shied away and settled on 5744------I bought a whole bunch of it at a real good price and never really looked back at Unique.

I use Unique in a dozen calibers.  When you add a small square of paper towel to position the powder it also raises the pressure slightly AND causes Unique to burn VERY cleanly (as in .405Win - a loooong case).

HAnk - check the loading data for Unique in a revolver ... pick the bullet weight and load for a rifle - No Issues
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Have been using Unique in handgun loads with cast bullets for 50 years. There are two important things to accuracy and clean burning. A good crimp with cases of a consistent lgt to make neck tension uniform and a powder measure that throws accurate charges. Unique is not the easiest powder to throw consistent charge weights with. It takes a good measure and practice with it. In a RCBS Uniflow I like the small capacity chamber and use a double tap on the bottom stroke as well as the up stroke. Have used it in 38spl, 357M, 41M, 44spl, 44M, and 45acp. It's a good powder in handgun cartridges. Also have been told that it works great in small capacity rifle cartridges with cast bullet loads. 
                                                Sendaro

Sendaro., I use the lee dip measures and then trickle, works out fine. Hank45

I've shot a lot of Unique in my pistols, but don't own a rifle in .45 Colt. My S&W Model 25-2 in .45 Colt is extremely accurate with a light 185 gr. SWC, and 6 grains of Unique. I use 8.5 grs. with a 250 gr. bullet and it's also a accurate load, and not too hot.

I've used Unique in 44 Mag revolver loads and 45 Colt loads in a Unerti Schuetzen single shot low wall I had. That powder always worked for me! I use a RCBS Lil' Dandy (revolver) or Belding&Mull (rifle) as powdah measures.

Dirty, dirty, dirty ... but the performance on paper never knew it !