At Rimfire Central this issue has been widely discussed. The spread and standard deviation with quality ammo, e.g., Wolf, Eley, SK, etc., regarding rim thickness (impacting leade or land engagement (?)) and weight of the cartridges (powder, bullet weight) is small resulting in tighter groups, fewer flyers. Better quality is more consistent ammo. Still need to test what works well in each individual rifle. Different lots of the same ammunition make for different impacts, i.e., buy a bunch if it works. If segregating by measuring and weighing gives someone more confidence, so much the better.
Regarding buying mid-grade ammo for practice, e.g., Federal 510, some have tried 22LR sizing dies, e.g., PACO ($45-128), Waltz($125). I have one of them, testing proved inconclusive (mostly me). But I'm told these dies will not make quality ammo better but will improve the consistency of mid/low grade ammo - for practicing. These dies also reform the tip, e.g., flat, HP.
For a CZ453, I measure rim thickness and weigh Wolf MT and Fed 510, and I see a definite improvement. It's anal, but I enjoy doing it while watching TV and it improves my confidence that flyers are my fault, which I'm not surprised.