WWBen47,
Welcome to the board! I don't know about a single shot 25-20 but I have a .22 hornet H&R 1871, and my cousin has one of the NEF guns. They are essentially the same other than finish and stocks and both pretty accurate. I have been considering taking mine out for turkey this spring, it just feels right to me. I can shoot it and know where it is going.
Do you mean 25-20 winchester or 25-20ss? I assumed winchester. I would think they would be good turkey guns and have also read accounts of the 100+ yds that you mentioned. I know that guys in the target world shoot the 25-20ss to some pretty impressive groups at 200 if the conditions are right. I have read of people experimenting with the 25-20 winchester for target work but don't remember the results. I have wondered if it can be made as accurate as the SS. I have been trying to figure out what to do with one of my crusty ballards and keep leaning towards lining it in 25 cal. But keep trying to decide between 25-20ss or the winchester version. 
It just dawned on me that the Thompson Contender was once available for the 25-20 wcf and probably still is from Fox River, their custom shop.

once again, welcome aboard!
MerwinBray

Interesting that you posted this today.  I received one of my turkey tags in the mail today and since one of the states I usually chase turkeys in each spring allows hunting them with a rifle I have been considering trying one.  I recently aquired an original Winchester lo-wall in 25-20SS and was thinking it might make a good turkey rifle.  I know the 22 hornet is a good turkey round and have freinds that have used Ruger No 1's and bolt actions for turkey with good success.

Well hey Moody..We must be "huntin neighbors"..Myself and two friends have a camp on Little Creek in Greenbrier County...Come and join us sometime..We dont kill a lot anymore..but we sure eat good.  Is 25/20SS..Sharps Straight?
Wes

Make sure you check if it is legal to use. In Iowa it has to be a shotgun with no larger then #4 shot, your state may have simalar rules

Brent, there's a few of us on this list.

David
Montezuma, IA
Ordered lumber today to convert half my garage into a gunsmithing/machine shop.  Start cutting wood and pounding nails tomorrow.  This formerly desk-bound sloth is going to be sore!   

Brent, after twenty years in the Tech department, the B company decided that my services were no longer desired.   

I've shot at Steamboat in the past, and am planning on it occasionally for this year, depending of course, on my employment situation.  (If someone offered me $75G to commute to Ames, I wouldn't turn it down, but I would like to stay local!)  I'm trying to get a machine shop/gunsmithing shop open to avoid the inconveniences of poverty and hunger.      

David Kaiser
Montezuma, IA

David it sounds like you're in the same boat I'm in.  After years of dedicated service helping a company grow, a new executive decided it was out with the old and bring in the new.  So as of last week, I'm out.  The bright side is it happened just in time for turkey season.